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ID: ALA1130707
Journal: Bioorg Med Chem Lett
Title: Inhibition stereochemistry of hydroxamate inhibitors for thermolysin.
Authors: Jin Y, Kim DH.
Abstract: N-Acyl-N-hydroxy-beta-amino acid derivatives were prepared and tested as inhibitors for thermolysin to find that these inhibitors show the L-stereospecificity in contrast to the corresponding hydroxamates prepared from alpha-amino acid, which exhibit the D-stereochemistry. N-Formyl-N-hydroxy-beta-L-Phe-NHMe is the most potent inhibitor having the Ki value of 1.66 microM.
CiteXplore: 9934463