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ID: ALA1130741
Journal: Bioorg Med Chem Lett
Title: Carboxy-substituted 2-azetidinones as cholesterol absorption inhibitors.
Authors: Vaccaro WD, Sher R, Davis HR.
Abstract: Metabolism initiated SAR studies led to the discovery of a new class of potent 2-azetidinone cholesterol absorption inhibitors. These studies found that a heteroatom at the para position of the C-4 phenyl ring is not a requirement for cholesterol absorption inhibition as was suggested by earlier findings. Substitution of Ph-linker-COOR for PhOMe at the C-4 position enhanced cholesterol absorption inhibition.
CiteXplore: 9871677