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ID: ALA1130744
Journal: Bioorg Med Chem Lett
Title: Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.
Authors: Adams J, Behnke M, Chen S, Cruickshank AA, Dick LR, Grenier L, Klunder JM, Ma YT, Plamondon L, Stein RL.
Abstract: Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.
CiteXplore: 9871680