Document Report Card
Basic Information
ID: ALA1130753
Journal: Bioorg Med Chem Lett
Title: Solid phase synthesis of a biased mini tetrapeptoid-library for the discovery of monodentate ITAM mimics as ZAP-70 inhibitors.
Authors: Révész L, Bonne F, Manning U, Zuber JF.
Abstract: The biased library was composed of a novel phosphotyrosine mimic fixed in the P1 position of a tetrapeptoid and combined with three lipophilic N-substituents at the remaining positions giving a total of 27 single compounds. Screening for ZAP-70 antagonism identified 8 as a novel selective monodentate ZAP-70 antagonist and lead in the search for new immunosuppressive drugs.
CiteXplore: 9871587