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ID: ALA1130754
Journal: Bioorg Med Chem Lett
Title: Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR).
Authors: Ahmed S, Denison S.
Abstract: Preliminary results of a modelling study of both steroidal and non-steroidal inhibitors of 5 alpha-reductase (5AR) are described in order to elucidate the essential structural requirements needed for the design of novel non-steroidal inhibitors. The study suggests that: (i) there is a requirement for groups to mimic the C(3) = O of the steroid substrate A-ring; (ii) the area of the active site about the C(17)-OH position of the substrate does not appear to possess hydrogen bonding groups and is unrestricted.
CiteXplore: 9871588