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ID: ALA1130759
Journal: Bioorg Med Chem Lett
Title: A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.
Authors: Guay D, Gauthier JY, Dufresne C, Jones TR, McAuliffe M, McFarlane C, Metters KM, Prasit P, Rochette C, Roy P, Sawyer N, Zamboni R.
Abstract: The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.
CiteXplore: 9871597