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ID: ALA1130766
Journal: Bioorg Med Chem Lett
Title: Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds.
Authors: Segarra V, Crespo MI, Pujol F, Beleta J, Doménech T, Miralpeix M, Palacios JM, Castro A, Martinez A.
Abstract: A 4-centre PDE4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.
CiteXplore: 9871607