Document Report Card
Basic Information
ID: ALA1130788
Journal: Bioorg Med Chem Lett
Title: Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.
Authors: Kanda Y, Ashizawa T, Saitoh Y, Saito H, Gomi K, Okabe M.
Abstract: A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.
CiteXplore: 9871510