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ID: ALA1130797
Journal: Bioorg Med Chem Lett
Title: A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase.
Authors: Dollinger LM, Howell AR.
Abstract: The 2-methyleneoxetane analog 2 of orlistat (OLS, 1) has been synthesized and tested against porcine pancreatic lipase (PPL). Despite the loss of the carbonyl group, a potential site for hydrogen bonding interaction with the enzyme and the key element in the acylation by OLS, 2 has activity comparable to 1.
CiteXplore: 9871523