PF1022A--a novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues.

ID: ALA1130801

Journal: Bioorg Med Chem Lett

Title: PF1022A--a novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues.

Authors: Scherkenbeck J, Harder A, Plant A, Dyker H.

Abstract: The first structure-activity relationships of the anthelmintic cyclooctadepsipeptide PF1022A have been established via a systematic exchange of the leucine residues by a series of related N-alkylated amino acids. The data presented strongly suggest that (L)-N-methyl-leucine is crucial for high in vivo activity.

CiteXplore: 9871703

DOI: 10.1016/s0960-894x(98)00156-5

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