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ID: ALA1130815
Journal: Bioorg Med Chem Lett
Title: Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles.
Authors: Katsura Y, Nishino S, Tomishi T, Sakane K, Matsumoto Y, Ishikawa H, Takasugi H.
Abstract: SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.
CiteXplore: 9871756