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ID: ALA1130826
Journal: Bioorg Med Chem Lett
Title: Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
Authors: Bellier B, Da Nascimento S, Meudal H, Gincel E, Roques BP, Garbay C.
Abstract: A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.
CiteXplore: 9871777