8-Aminoquinolines as anticoccidials--II.
Basic Information
ID: ALA1130837
Journal: Bioorg Med Chem Lett
Title: 8-Aminoquinolines as anticoccidials--II.
Authors: Armer RE, Barlow JS, Dutton CJ, Greenway DH, Greenwood SD, Lad N, Thompson AP, Thong KW, Tommasini I.
Abstract: During a chemistry program aimed at finding a novel analogue of pentaquine with improved in vivo activity, a number of hypotheses concerning the way this drug acts in the chicken were investigated. Consideration of the products of monoamine oxidase metabolism of pentaquine suggested that pentaquine aldehyde is the likely active metabolite. Although isolation of this unstable compound was not possible, oxime and cyclic acetal and ketal derivatives were obtained and shown to possess in vitro anticoccidial activity.
CiteXplore: 9873375
DOI: 10.1016/s0960-894x(98)00243-1
Patent ID: ┄