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ID: ALA1130886

Journal: Bioorg Med Chem Lett

Title: Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

Authors: Elliott JM, Cascieri MA, Chicchi G, Davies S, Kelleher FJ, Kurtz M, Ladduwahetty T, Lewis RT, MacLeod AM, Merchant KJ, Sadowski S, Stevenson GI.

Abstract: A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

CiteXplore: 9873445

DOI: 10.1016/s0960-894x(98)00320-5