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ID: ALA1130909
Journal: Bioorg Med Chem Lett
Title: General construction pattern of histamine H3-receptor antagonists: change of a paradigm.
Authors: Stark H, Ligneau X, Arrang JM, Schwartz JC, Schunack W.
Abstract: Novel omega-phenyl substituted and unsubstituted alkyl and alkenyl imidazole derivatives were prepared and tested for their antagonist activity in vitro and in vivo at histamine H3-receptors. Some compounds showed high in vitro and in vivo H3-receptor activity despite their structure bearing no polar moiety in the centre of the molecule which is a common structural feature of all other antagonists known. Quite probably there are further in vivo effects for some compounds resulting from other receptor interactions.
CiteXplore: 9873477