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ID: ALA1130930
Journal: Bioorg Med Chem Lett
Title: In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
Authors: Xu ZQ, Buckheit RW, Stup TL, Flavin MT, Khilevich A, Rizzo JD, Lin L, Zembower DE.
Abstract: The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.
CiteXplore: 9873509