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ID: ALA1130941
Journal: Bioorg Med Chem Lett
Title: Comparison of the intrinsic kinase activity and substrate specificity of c-Abl and Bcr-Abl.
Authors: Wu JJ, Phan H, Lam KS.
Abstract: We studied the intrinsic tyrosine kinase activity and substrate specificity of c-Abl and Bcr-Abl protein tyrosine kinases (PTKs) using the peptide substrates discovered from a synthetic combinatorial peptide library. Our data indicate that the phosphorylation of these peptides by Bcr-Abl was consistently stronger than that by c-Abl. Bcr-Abl also showed substrate preference towards those peptides with one or more positive charges.
CiteXplore: 9873528