Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

ID: ALA1130950

Journal: Bioorg Med Chem Lett

Title: Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

Authors: Yuen P, Schelkun RM, Szoke B, Tarczy-Hornoch K.

Abstract: Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein.

CiteXplore: 9873552

DOI: 10.1016/s0960-894x(98)00440-5

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