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ID: ALA1130976
Journal: Bioorg Med Chem Lett
Title: 5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.
Authors: Auberson YP, Bischoff S, Moretti R, Schmutz M, Veenstra SJ.
Abstract: A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.
CiteXplore: 9871630