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ID: ALA1130981

Journal: Bioorg Med Chem Lett

Title: DNA gyrase inhibitory activity of ellagic acid derivatives.

Authors: Weinder-Wells MA, Altom J, Fernandez J, Fraga-Spano SA, Hilliard J, Ohemeng K, Barrett JF.

Abstract: Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.

CiteXplore: 9871636

DOI: 10.1016/s0960-894x(97)10197-4