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ID: ALA1130993
Journal: Bioorg Med Chem Lett
Title: 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors.
Authors: Harmat NJ, Di Bugno C, Criscuoli M, Giorgi R, Lippi A, Martinelli A, Monti S, Subissi A.
Abstract: A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
CiteXplore: 9871744