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ID: ALA1130994
Journal: Bioorg Med Chem Lett
Title: 3-trifluoromethylcarbacephems: synthesis of broad spectrum antibacterial compounds.
Authors: Cook GK, Hornback WJ, McDonald JH, Munroe JE, Snyder NJ.
Abstract: The enhanced stability of the carbacephem nucleus over the corresponding cephalosporin nucleus has allowed the synthesis of 7-arylglycyl-3-trifluoromethyl-carbacephems. These unique carbacephems possess broad spectrum activity and high stability to both plasmid and chromosomally mediated beta-lactamases.
CiteXplore: 9871746