Document Report Card

ID: ALA1131155

Journal: J Med Chem

Title: Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.

Authors: Zeng Q, Kwok Y, Kerwin SM, Mangold G, Hurley LH.

Abstract: A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC50 values. Their cytotoxic potency correlates with their ability to unwind DNA and inhibit topoisomerase II.

CiteXplore: 9784102

DOI: 10.1021/jm980265c