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ID: ALA1131268

Journal: Bioorg Med Chem Lett

Title: Preparation of biotinylated allosamidins with strong chitinase inhibitory activities.

Authors: Sakuda S, Sakurada M.

Abstract: NaIO4 oxidation of allosamidin (1), a strong inhibitor of family 18 chitinases, followed by a coupling with Biotin Hydrazide afforded its mono- and dibiotinylated derivatives, 4 and 6. Reduction of 4 by NaBH4 afforded its reduced form 5. Each of these three biotinylated derivatives maintained strong chitinase inhibitory activity. Especially, 6 inhibited a Trichoderma chitinase as strongly as 1.

CiteXplore: 9873660

DOI: 10.1016/s0960-894x(98)00542-3