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ID: ALA1131359
Journal: Bioorg Med Chem Lett
Title: Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Authors: Sasaki S, Hashimoto T, Obana N, Yasuda H, Uehara Y, Maeda M.
Abstract: New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac-Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.
CiteXplore: 9871700