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ID: ALA1131363
Journal: Bioorg Med Chem Lett
Title: Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
Authors: Belliotti TR, Brink WA, Kesten SR, Rubin JR, Wustrow DJ, Zoski KT, Whetzel SZ, Corbin AE, Pugsley TA, Heffner TG, Wise LD.
Abstract: PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
CiteXplore: 9873377