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ID: ALA1131371
Journal: Bioorg Med Chem Lett
Title: H-phosphonate derivatives as novel peptide deformylase inhibitors.
Authors: Hu YJ, Rajagopalan PT, Pei D.
Abstract: Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. Its absence from eukaryotic organisms makes it an attractive target for designing novel antibacterial agents. Peptidyl H-phosphonates were synthesized and shown to be competitive inhibitors of the deformylase.
CiteXplore: 9873565