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ID: ALA1131388
Journal: Bioorg Med Chem Lett
Title: Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones.
Authors: Jung SH, Lee HS, Song JS, Kim HM, Han SB, Lee CW, Lee M, Choi DR, Lee JA, Chung YH, Yoon SJ, Moon EY, Hwang HS, Seong SK, Lee DK.
Abstract: Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolon es 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
CiteXplore: 9873387