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ID: ALA1131405
Journal: Bioorg Med Chem Lett
Title: Novel bisphosphonate inhibitors of phosphoglycerate kinase.
Authors: Caplan NA, Pogson CI, Hayes DJ, Blackburn GM.
Abstract: A series of novel, conformationally-restrained bisphosphonate analogues of 1,3-bisphosphoglyceric acid 1 have been synthesised and evaluated as inhibitors of 3-PGK. They are competitive inhibitors of the human enzyme and, especially for certain alpha-halophosphonic acid analogues, both Ki and IC50 values extend into the submicromolar range.
CiteXplore: 9871609