A new antitumor agent: methyl sulfonium perchlorate of echinomycin.

ID: ALA1131512

Journal: Bioorg Med Chem Lett

Title: A new antitumor agent: methyl sulfonium perchlorate of echinomycin.

Authors: Park YS, Kim YH, Kim SK, Choi SJ.

Abstract: Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16.

CiteXplore: 9871531

DOI: 10.1016/s0960-894x(98)00113-9

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