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ID: ALA1131513
Journal: Bioorg Med Chem Lett
Title: SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities.
Authors: Sui Z, Guan J, Hlasta DJ, Macielag MJ, Foleno BD, Goldschmidt RM, Loeloff MJ, Webb GC, Barrett JF.
Abstract: A series of diaryltriazole analogs was discovered to inhibit bacterial two-component regulatory systems in our primary assays, KinA/Spo0F and NRII/NRI. They also showed inhibitory activity in whole cell mechanism-based assays, and they possessed potent activities against several strains of Gram-positive pathogenic bacteria in the standard MIC broth assay.
CiteXplore: 9873461