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ID: ALA1131518

Journal: Bioorg Med Chem Lett

Title: Methionine analogues as inhibitors of methionyl-tRNA synthetase.

Authors: Lee J, Kang MK, Chun MW, Jo YJ, Kwak JH, Kim S.

Abstract: A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with Ki = 19 microM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.

CiteXplore: 9934462

DOI: 10.1016/s0960-894x(98)00642-8