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ID: ALA1131541
Journal: Bioorg Med Chem Lett
Title: New synthetic inhibitors of microtubule depolymerization.
Authors: Klar U, Graf H, Schenk O, Röhr B, Schulz H.
Abstract: A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.
CiteXplore: 9871773