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ID: ALA1131542
Journal: Bioorg Med Chem Lett
Title: A potent dipeptide inhibitor of dipeptidyl peptidase IV.
Authors: Yamada M, Okagaki C, Higashijima T, Tanaka S, Ohnuki T, Sugita T.
Abstract: A series of novel potent inhibitors of dipeptidyl peptidase IV (DPP-IV) has been developed. A brief structure-activity relationship of the inhibitors was investigated. The dipeptide TSL-225, tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, was identified with the critical structure for the inhibitory activity.
CiteXplore: 9873385