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ID: ALA1131549
Journal: Bioorg Med Chem Lett
Title: Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase.
Authors: Williams DM, Jakeman DL, Vyle JS, Williamson MP, Blackburn GM.
Abstract: Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesized with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Their Kds decrease with net negative charge, with a penta-anionic analogue 7 showing highest affinity-in accordance with its approximation to the transition state for the reaction catalysed by PGK.
CiteXplore: 9873589