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ID: ALA1131549

Journal: Bioorg Med Chem Lett

Title: Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase.

Authors: Williams DM, Jakeman DL, Vyle JS, Williamson MP, Blackburn GM.

Abstract: Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesized with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Their Kds decrease with net negative charge, with a penta-anionic analogue 7 showing highest affinity-in accordance with its approximation to the transition state for the reaction catalysed by PGK.

CiteXplore: 9873589

DOI: 10.1016/s0960-894x(98)00466-1