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ID: ALA1131641
Journal: Bioorg Med Chem Lett
Title: Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Authors: Beall HD, Hudnott AR, Winski S, Siegel D, Swann E, Ross D, Moody CJ.
Abstract: A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
CiteXplore: 9871615