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ID: ALA1131647
Journal: Bioorg Med Chem Lett
Title: Enzymatic synthesis of a modified phospholipid and its evaluation as a substrate for B. cereus phospholipase C.
Authors: Martin SF, Hergenrother PJ.
Abstract: The novel phospholipid 2, which bears a tert-butyl moiety in place of the natural trimethyl ammonium group of phosphatidylcholine, has been enzymatically synthesized via a transphosphatidylation reaction mediated by phospholipase D. The change from the choline headgroup in 1 to the tert-butyl group in 2 reduced the efficiency of hydrolysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus by a factor of greater than 10(3).
CiteXplore: 9871566