Document Report Card
Basic Information
ID: ALA1131652
Journal: Bioorg Med Chem Lett
Title: Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
Authors: Tomasi S, Le Roch M, Renault J, Corbel JC, Uriac P, Carboni B, Moncoq D, Martin B, Delcros JG.
Abstract: A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.
CiteXplore: 9871574