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ID: ALA1131655
Journal: Bioorg Med Chem Lett
Title: Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.
Authors: Camp D, Green JM, Kaiser SM, Moni RW, Townsend-Nicholson A, Schofield PR, Quinn RJ.
Abstract: Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.
CiteXplore: 9871584