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ID: ALA1131668
Journal: Bioorg Med Chem Lett
Title: Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.
Authors: Beck JP, Arvanitis AG, Curry MA, Rescinito JT, Fitzgerald LW, Gilligan PJ, Zaczek R, Trainor GL.
Abstract: A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
CiteXplore: 10230622