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ID: ALA1131681
Journal: Bioorg Med Chem Lett
Title: Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.
Authors: Beck JP, Curry MA, Chorvat RJ, Fitzgerald LW, Gilligan PJ, Zaczek R, Trainor GL.
Abstract: A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.
CiteXplore: 10328310