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ID: ALA1131696
Journal: Bioorg Med Chem Lett
Title: Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.
Authors: de la Figuera N, Martín-Martínez M, Herranz R, García-López MT, Latorre M, Cenarruzabeitia E, del Río J, González-Muñiz R.
Abstract: Conformationally constrained dipeptoid analogues containing the type II' beta-turn mimic (2S,5s,11bR)-2-amino-3-oxohexahydroindolizino[8,7-b]indole-5 -carboxylate framework in place of the alpha-MeTrp residue, show high binding affinity and selectivity for CCK-A receptors, suggesting that a turn-like conformation could contribute to the bioactive conformation at this CCK receptor subtype.
CiteXplore: 9990454