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ID: ALA1131701
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors.
Authors: Ho GD, Silverman L, Bercovici A, Puchalski C, Tulshian D, Xia Y, Czarniecki M, Green M, Cleven R, Zhang H, Fawzi A.
Abstract: Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.
CiteXplore: 9990447