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ID: ALA1131713
Journal: Bioorg Med Chem Lett
Title: Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.
Authors: Vieira E, Binggeli A, Breu V, Bur D, Fischli W, Güller R, Hirth G, Märki HP, Müller M, Oefner C, Scalone M, Stadler H, Wilhelm M, Wostl W.
Abstract: The identification, synthesis and activity of a novel class of piperidine renin inhibitors is presented. The most active compounds show activities in the picomolar range and are among the most potent renin inhibitors ever identified.
CiteXplore: 10360744