Phosphofurylalanine, a stable analog of phosphohistidine.
Basic Information
ID: ALA1131720
Journal: Bioorg Med Chem Lett
Title: Phosphofurylalanine, a stable analog of phosphohistidine.
Authors: Schenkels C, Erni B, Reymond JL.
Abstract: Phosphorylated histidine residues occur in a number of signal-transduction pathways in bacteria as well as in eukaryotes. Phosphohistidine is hydrolytically labile and therefore difficult to study, this by contrast to stable phosphoserine, phosphothreonine or phosphotyrosine. Here we report the design and enantioselective synthesis of (4'-phospho-2'-furyl)alanine 1, a non-hydrolyzable analog of 1-phosphohistidine. This novel amino-acid should be useful to synthesize peptides incorporating a stable analog phosphohistidine.
CiteXplore: 10360753
DOI: 10.1016/s0960-894x(99)00209-7
Patent ID: ┄