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ID: ALA1131728
Journal: Bioorg Med Chem Lett
Title: Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Authors: Chen H, Roques BP, Fournié-Zaluski MC.
Abstract: A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designed to date.
CiteXplore: 10386926