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ID: ALA1131753
Journal: Bioorg Med Chem Lett
Title: Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.
Authors: Wender PA, Lippa B, Park CM, Irie K, Nakahara A, Ohigashi H.
Abstract: Designed bryostatin analogues are assayed for binding affinity to individual cysteine rich domains of several protein kinase C (PKC) isozymes. These analogues exhibit significant selectivity for the PKCdelta-C1B peptide in terms of absolute affinity and the PKCdelta-C1A peptide in terms of relative affinity when compared to phorbol-12,13-dibutyrate.
CiteXplore: 10397502