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ID: ALA1131761

Journal: Bioorg Med Chem Lett

Title: Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.

Authors: Zhang L, Williams MA, Mendel DB, Escarpe PA, Chen X, Wang KY, Graves BJ, Lawton G, Kim CU.

Abstract: 1,4,5,6-Tetrahydropyridazine derivative 15 and its C-5 epimer 19, which possessed side chains similar to GS4071, were synthesized via a hetero Diels-Alder reaction, and evaluated as influenza neuraminidase inhibitors. Compounds 15 and 19 exhibited a microM range of influenza neuraminidase inhibitory activity.

CiteXplore: 10406636

DOI: 10.1016/s0960-894x(99)00280-2