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ID: ALA1131788
Journal: Bioorg Med Chem Lett
Title: Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum.
Authors: Chu M, Mierzwa R, He L, King A, Patel M, Pichardo J, Hart A, Butkiewicz N, Puar MS.
Abstract: A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 (1) was isolated from the fungus, Penicillium griseofulvum. Structure elucidation of 1 was accomplished by analysis of spectroscopic data, which determined compound 1 to be a bicyclic hemiketal lactone. Compound 1 exhibited inhibitory activity in the HCV protease assay with an IC50 value of 3.8 microg/mL.
CiteXplore: 10450960