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ID: ALA1131818
Journal: Bioorg Med Chem Lett
Title: Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
Authors: Fryatt T, Goroski DT, Nilson ZD, Moody CJ, Beall HD.
Abstract: The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
CiteXplore: 10465544